Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function.

Autocrine IFN-g Promotes Naive CD8 T Cell Differentiation and Synergizes with IFN-a To Stimulate Strong Function

Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production.

Naive CD4(+) T cells require signals from the TCR and CD28 to produce IL-2, expand, and differentiate. However, these same signals are not sufficient to induce autocrine IL-2 production by naive CD8(+) T cells, which require cytokines provided by other cell types to drive their differentiation. The basis for failed autocrine IL-2 production by activated CD8(+) cells is unclear. We find that Ika...

CCD107a Expression and IFN-γ Production as Markers for Evaluation of Cytotoxic CD3+ CD8+ T Cell Response to CMV Antigen in Women with Recurrent Spontaneous Abortion

بررسی مقادیر سرمی اینترفرون گاما، اینترلوکین 12 و درصد سلولهای ایمنی CD8، CD4 و NK در زنان مبتلا به سرطان پستان متاستاتیک، غیرمتاستاتیک و افراد سالم

    Background & Aim: The immune system is quite capable to combat tumors and many immunological parameters including cytokines such as IL-12 & IFN-γ play major roles in this regard. IL-12 is also the major cytokine responsible for the differentiation of TH1 cells, which are potent producers of IFN-γ, IFN-γ in turn has a powerful enhancing effect on the ability of phagocytes to produce IL-12 as...

بررسی اثر تماس مستقیم سلولهایT بکر با سلولهای فیبروبلاست تحریک شده با BCG بر القای سلولهایT تنظیمی

Background: Lymph node stromal fibroblasts are interconnected with TCD4+ cells and affect their phenotype and function. Understanding the nature of these interactions under unusual conditions like infections will help to their application in control and regulation of immune responses. Materials and methods: Lymph node fibroblasts were affected in BCG primed immune environment by both in-...